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Discovery of a new intestinal virus


Scientists have discovered a previously unknown virus that lives in the human gut, according to a study published in Nature Communications.

An international team of scientists discovered the virus in CrAssphage genetic material from samples of intestine. Scientists believe the virus can affect the behavior of some of the most common bacteria in the intestinal flora.

Experts explain that these types of viruses called bacteriophages play an important role in chronic diseases. Leading a team from the State University at San Diego, USA, “clears” the genetic information that is stored in three large international databases. Continue reading

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The mitochondrial electrochemical gradient is often disturbed during apoptosis and can be detected using cationic dyes such as DePsipher™ (5,5’6,6’- tetrachloro-1,1’,3,3’-tetraethylbenz-imidazolylcarbocyanine iodide) or MitoShift™ (tetramethylrhodamine ethyl ester).

Activation of caspases, or cysteinyl proteases, is a necessary event for execution of the apoptotic response.  Some of the caspases Continue reading

Gene editing treat rare liver disease

Using a new system of genetic editing based on bacterial proteins by researchers from MIT cured rare liver disease caused by a single genetic mutation.gentaur-gene

The findings described in the edition of Nature Biotechnology, provide the first evidence that the technique of editing of a gene known as CRISPR, can reverse disease symptoms.

CRISPR, which offers an easy way to crop the mutatedDNA and replacement with the correct sequence has the potential to treat many genetic diseases, according to the research team.

Recently developed CRISPR system relies on cellular mechanism that bacteria use to protect themselves from viral infection.

Researchers have copied this cell system for the creation of gene-editing complexes, including DNA.

They are cut enzyme called Cas9, bound to the RNA strand, which can be programmed to bind to a specific genomic sequence.

Meanwhile, researchers deliver DNA template strand.

When repairing cell damage resulting from Cas9, scientists introduced the template DNA in the genome.

Scientists predict that this type of revision of the genome one day could help in the treatment of diseases such as hemophilia, Huntington’s disease, and the like, caused by a single mutation.

There are other systems developed on the basis of genetic editing of DNA enzymes known as nucleases, but these complexes can be expensive and difficult to assemble.

In contrast, CRISPR is very easy to configure and customize equipment.

Protein in the body – effective against hepatitis C

Gentaur proteinProtein in the body can improve its ability to detect and treat viral infections such as influenza and hepatitis C. This conclusion leads a laboratory study by researchers from the University Institute of cancer in Pittsburgh, USA. 
To start playback in the body, the virus actually “invaded”cells and “takes” control over them. 
Experts explain that, despite progress in the field of vaccines and treatment diseases caused by viral infections remain among the leading causes of death in the world. According to them, there is a need for a new type of security and the new discovery appears to be promising for further studies. 
Scientists isolated protein of similar oligoadenylate synthetase-occurring in humans, suffering from liver cancer, caused by hepatitis C. When the Expert increase the levels of this protein in human cells, observed inhibition of virus replication. 
In later study found that murine organisms in which there is no presence of the protein are susceptible to a large extent of a viral infection, in comparison to those who have it. 

Viruses affect the ribonucleic acid (RNA), including hepatitis C, influenza and respiratory syncytial virus, using RNA as the genetic material, when played back. 
The types of treatment, based on the protein like oligoadenylate synthetase, can enhance the ability of cells to detect RNA, used by the virus, and thus to activate the immune system to stop its reproduction.